The most advanced, comprehensive and effective medical treatment for Kidney Stones.
Lit-Control is a revolutionary medical treatment for Kidney Stones combining the
most recent scientific advances in nutritional therapy with digital technologies.
Lit-Control is a family of four innovative medical foods that have been formulated to treat and manage the nutritional needs of patients with each of the four major groups of Kidney Stones (i.e. calcium, uric acid, infectious and cytine stones). And in combination with these medical foods, Lit-Control also incorporates a ground-breaking digital therapeutic to ease the follow-up of these patients.
Lit-Control pH Up
Lit-Control pH Up is an innovative medical food intended for the treatment of patients with uric acid stones. This product, patent protected and clinically proven, combines two mechanism of actions; the increase of the urine pH because of the magnesium-potassium-citrate, and the inhibition of uric acid crystallization because of the theobromine.
Lit-Control pH Down
Lit-Control pH Down is an innovative medical food intended for the treatment of patients with infectious stones. This product, patent protected and clinically proven, reduce the formation of infectious stones such as struvite, carbonate apatite and brushite, through the acidification of the urine with L-methionine.
Lit-Control pH Balance
Lit-Control pH Balance is an innovative medical food intended for the treatment of patients with calcium stones. This product, patent protected and clinically proven, reduce the formation of calcium stones such as calcium oxalate and calcium phosphate, through the inhibition of the calcium salts crystallization with phytate, the complexation of the urinary oxalate with magnesium, and the protection of the papillary damage with antioxidants.
Lit-Control pH Meter
Lit-Control pH Meter is an innovative first-in-class medical device intended to measure the urine pH of stone-formers with excellent outcomes in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy. This product, patent protected and clinically proven, is the best option to measure the pH in a fresh urine (just after the urination) to take quick and reliable clinical decisions in the doctor's office, or to monitor the patient's urine pH during the day (circadian rhythms) easily and conveniently at home.
SPECIFIC STRENGTHS OF LIT-CONTROL
Patent protected, technologically advanced
A new device for simple and accurate urinary pH testing by the Stone-former patient
At present, dipstick testing is largely used to estimate urinary pH, however, the accuracy of this method may be insufficient for making clinical decisions in patients with lithiasis. We compared the accuracy of a new electronic device with dipstick pH strips using 30 fresh human urine samples. None of the measurements made with the new electronic device differed from the results of the pH-meter by more than 0.1 pH units. This new device can be used by stone-formers to control their urinary pH at home, increasing the tools available for stone prevention.
Evaluation of a Portable Urinary pH Meter and Reagent Strips
Measurements of urinary pH were obtained by use of reagent strips, a portable pH meter and a laboratory pH meter (gold standard). The mean matched pair difference between the gold standard and all other pH measurement methods was the smallest with the portable electronic pH meter (bias 0.01, 95% confidence interval [CI] -0.07 to 0.08; p = 0.89). Thus, Findings of this study support that the portable electronic pH meter is a reliable pH measuring device. It appears to be more accurate compared to reagent strips readings.
Urinary pH as a Target in the Management of Lithiasic Patients in Real-World Practice: Monitoring and Nutraceutical Intervention for a Nonlithogenic pH Range
The objective of the study is to assess the effectiveness of the joint use of a pH meter in combination with dietary supplements in restoring the urinary pH balance of patients with medical history ofUA or CP/CO stones in real-world practice.
Galan-Llopis JA, Torrecilla-Ortiz C, Luque-Gálvez MP, Group P-L, Peris-Nieto X, Cuñé-Castellana J. Urinary pH as a Target in the Management of Lithiasic Patients in Real-World Practice: Monitoring and Nutraceutical Intervention for a Nonlithogenic pH Range. Clin Med Insights Urol [Internet]. 2019;12:117956111985355
Combined Use of a Medical Device and a Dietary Complement in Patient Urinary pH Control in Patients With an Implanted Double J Stent
This study evaluates the effectivity in urinary pH Control and the prevention of calcification in Double J stent using a device combined with the intake of dietary supplements. Every patient will receive hygienic-dietary indications. Patients will also take one out of the three dietary supplements regarded within the study (pH Up, pH Down and Cysteine) to control the adequate pH level, always following medical indications.
This Study Evaluates the Superiority of Daily Self-pH Monitorization of Lit-Control pH Meter Compared to the Monitorization of Reactive Strips (Standard of Care)
This study evaluates the superiority of daily self-pH monitorization of Lit-Control pH meter compared to the monitorization of reactive strips (standard of care).
HPLC method for urinary theobromine determination: Effect of consumption of cocoa products on theobromine urinary excretion in children
To validate a method of urinary theobromine determination in 80 healthy children and to relate these levels to consumption of cocoa products. Urine samples were directly injected into an HPLC system and detected by UV spectrometry. The method was validated for linearity, limits of detection, accuracy, and interferences. It resulted in urinary theobromine determination with 100% recovery, and urinary theobromine levels in healthy children were directly related to their consumption of cocoa products.
Effect of Consumption of Cocoa-Derived Products on Uric Acid Crystallization in Urine of Healthy Volunteers
To determine the effects of consumption of different cocoa-derived products on uric acid crystallization in urine of 20 healthy volunteers. Participants selected a specific diet with 20 g of milk chocolate, chocolate powder, or dark chocolate. Overnight 12 h urine samples were then collected. The results show that uric acid crystallization was significantly lower following the consumption of chocolate powder or dark chocolate relative to baseline. Increased concentrations of urinary theobromine reduced the risk of uric acid crystallization.
Urolithiasis: Inhibitors of xanthine crystallization
To identify inhibitors of xanthine crystallization to prevent the development of the renal calculi in patients with xanthinuria. The effects of 10 potential crystallization inhibitors were assessed; results suggest that consumption of theobromine could protect patients with xanthinuria from the development of renal xanthine calculi. Clinical trials are necessary to demonstrate these effects in vivo.
Efficacy of Mixtures of Magnesium, Citrate and Phytate as Calcium Oxalate Crystallization Inhibitors in Urine
To evaluate the effectiveness of mixtures of magnesium, citrate and phytate as calcium oxalate crystallization inhibitors. A turbidimetric assay in synthetic urine was performed to obtain induction times for calcium oxalate crystallization in the absence and presence of different mixtures of inhibitors. Significant synergistic effects between magnesium and phytate were observed, suggesting that a combination of these 2 compounds may be highly useful as antilithiasis therapy.
Effect of L-Methionine on the Risk of Phosphate Stone Formation. Urology
Twelve healthy subjects were studied; after consuming a standardized diet for 5 days, participants received 1500 mg L-methionine at 9 AM at day6. 24-hour fractional urine collections were obtained. After single-dose administration of L-methionine, urinary pH decreased and the relative supersaturation of brushite and struvite decreased significantly by 25%. The present findings show that L-methionine effectively decreases urinary pH and the risk of struvite and calcium phosphate stone formation in healthy subjects.
Effects of polyphenols from grape seeds on renal lithiasis.
Many plant extracts that protect against oxidative stress manifest antilithiasic activity. Our study focused on determining the effects of polyphenols on a lithiasis rat model. Significant differences in the renal calcium content were observed between the control group and the one receiving grape seed extracts. The antioxidant activity of polyphenols extracted from red and white grape seeds may be critical in the prevention of calcium oxalate monohydrate papillary calculus formation.
Theobromine inhibits uric acid crystallization. A potential application in the treatment of uric acid nephrolithiasis
The purpose is to assess the capacity of methylxanthines, as theobromine, to inhibit uric acid crystallization. Crystal morphology and its modification because of theobromine were evaluated by scanning electron microscopy (SEM). The images showed that the presence of theobromine resulted in thinner uric acid crystals. Theobromine acts as an inhibitor of nucleation and crystal growth of uric acid and may be clinically useful in the treatment of uric acid nephrolithiasis.
Phytate in foods and significance for humans: Food sources, intake, processing, bioavailability, protective role and analysis (Review).
The article gives an overview of phytic acid in food and of its significance for human nutrition. It summarises phytate sources in foods and discusses problems of phytic acid/phytate contents of food tables.
Effects of inositol hexaphosphate (phytate) on calcium binding, calcium oxalate crystallization and in vitro Stone growth
We measured and compared 3 activities of inositol hexaphosphate, also known as phytate, to explore their importance in relation to antilithogenic potential.
Effects of phytate and pyrophosphate on brushite and hydroxyapatite crystallization: Comparison with the action of other polyphosphates
This is a comparative study of the effects of phytate and pyrophosphate and other polyphosphates on the crystallization of hydroxyapatite and brushite, the most frequent calcium phosphates involved in calcium oxalate urolithiasis. Brushite