Lit-Control

At present, dipstick testing is largely used to estimate urinary pH, however, the accuracy of this method may be insufficient for making clinical decisions in patients with lithiasis. We compared the accuracy of a new electronic device with dipstick pH strips using 30 fresh human urine samples. None of the measurements made with the new electronic device differed from the results of the pH-meter by more than 0.1 pH units. This new device can be used by stone-formers to control their urinary pH at home, increasing the tools available for stone prevention.

Measurements of urinary pH were obtained by use of reagent strips, a portable pH meter and a laboratory pH meter (gold standard). The mean matched pair difference between the gold standard and all other pH measurement methods was the smallest with the portable electronic pH meter (bias 0.01, 95% confidence interval [CI] -0.07 to 0.08; p = 0.89). Thus, Findings of this study support that the portable electronic pH meter is a reliable pH measuring device. It appears to be more accurate compared to reagent strips readings.

The objective of the study is to assess the effectiveness of the joint use of a pH meter in combination with dietary supplements in restoring the urinary pH balance of patients with medical history ofUA or CP/CO stones in real-world practice.

This study evaluates the effectivity in urinary pH Control and the prevention of calcification in Double J stent using a device combined with the intake of dietary supplements. Every patient will receive hygienic-dietary indications. Patients will also take one out of the three dietary supplements regarded within the study (pH Up, pH Down and Cysteine) to control the adequate pH level, always following medical indications.

This study evaluates the superiority of daily self-pH monitorization of Lit-Control pH meter compared to the monitorization of reactive strips (standard of care).

To validate a method of urinary theobromine determination in 80 healthy children and to relate these levels to consumption of cocoa products. Urine samples were directly injected into an HPLC system and detected by UV spectrometry. The method was validated for linearity, limits of detection, accuracy, and interferences. It resulted in urinary theobromine determination with 100% recovery, and urinary theobromine levels in healthy children were directly related to their consumption of cocoa products.

To determine the effects of consumption of different cocoa-derived products on uric acid crystallization in urine of 20 healthy volunteers. Participants selected a specific diet with 20 g of milk chocolate, chocolate powder, or dark chocolate. Overnight 12 h urine samples were then collected. The results show that uric acid crystallization was significantly lower following the consumption of chocolate powder or dark chocolate relative to baseline. Increased concentrations of urinary theobromine reduced the risk of uric acid crystallization.

To identify inhibitors of xanthine crystallization to prevent the development of the renal calculi in patients with xanthinuria. The effects of 10 potential crystallization inhibitors were assessed; results suggest that consumption of theobromine could protect patients with xanthinuria from the development of renal xanthine calculi. Clinical trials are necessary to demonstrate these effects in vivo.

To evaluate the effectiveness of mixtures of magnesium, citrate and phytate as calcium oxalate crystallization inhibitors. A turbidimetric assay in synthetic urine was performed to obtain induction times for calcium oxalate crystallization in the absence and presence of different mixtures of inhibitors. Significant synergistic effects between magnesium and phytate were observed, suggesting that a combination of these 2 compounds may be highly useful as antilithiasis therapy.

Twelve healthy subjects were studied; after consuming a standardized diet for 5 days, participants received 1500 mg L-methionine at 9 AM at day6. 24-hour fractional urine collections were obtained. After single-dose administration of L-methionine, urinary pH decreased and the relative supersaturation of brushite and struvite decreased significantly by 25%. The present findings show that L-methionine effectively decreases urinary pH and the risk of struvite and calcium phosphate stone formation in healthy subjects.

Many plant extracts that protect against oxidative stress manifest antilithiasic activity. Our study focused on determining the effects of polyphenols on a lithiasis rat model. Significant differences in the renal calcium content were observed between the control group and the one receiving grape seed extracts. The antioxidant activity of polyphenols extracted from red and white grape seeds may be critical in the prevention of calcium oxalate monohydrate papillary calculus formation.

The purpose is to assess the capacity of methylxanthines, as theobromine, to inhibit uric acid crystallization. Crystal morphology and its modification because of theobromine were evaluated by scanning electron microscopy (SEM). The images showed that the presence of theobromine resulted in thinner uric acid crystals. Theobromine acts as an inhibitor of nucleation and crystal growth of uric acid and may be clinically useful in the treatment of uric acid nephrolithiasis.

The article gives an overview of phytic acid in food and of its significance for human nutrition. It summarises phytate sources in foods and discusses problems of phytic acid/phytate contents of food tables.

We measured and compared 3 activities of inositol hexaphosphate, also known as phytate, to explore their importance in relation to antilithogenic potential.

This is a comparative study of the effects of phytate and pyrophosphate and other polyphosphates on the crystallization of hydroxyapatite and brushite, the most frequent calcium phosphates involved in calcium oxalate urolithiasis. Brushite