Canoxidin®

L-Methionine helps to lower urinary pH, thus helping to prevent hydroxyapatite crystallization on the surface of the urological device. In addition, it counteracts the alkalization caused by urease-positive bacteria adhering to the surface of the urological device.

Phytate, on the other hand, is the most potent inhibitor of the crystallization of urinary hydroxyapatite and calcium oxalate salts. 

And Theobromine acts as a molecular imposter of uric acid and other salts, preventing their crystallization on the surface of the urological device.

This combination of ingredients has been shown to reduce the likelihood of catheter encrustation by more than 8 times. *² In addition, the presence of crystallization inhibitors such as Phytate, significantly eliminate the formation of calcium oxalate crystals. *³

Presentation: 90 tablets

National Code: 209034.7

*¹ Grases F, Julià F, Calvó P, Costa-Bauzá A, Bernades M, Mira Ll, Sánchez A, Chiganças V, González E, Cuñé J. Study of encrustation in Foley urinary catheters in patients with cognitive failure and spinal cord injury. Identification of high encrustation areas and crystallographic characterization.

*² Torrecilla, C., Fernández-Concha, J., Cansino, J. R., Mainez, J. A., Amón, J. H., Costas, S., Angerri, O., Emiliani, E., Arrabal Martín, M. A., Arrabal Polo, M. A., García, A., Reina, M. C., Sánchez, J. F., Budía, A., Pérez-Fentes, D., Grases, F., Costa-Bauzá, A., & Cuñé, J. (2020). Reduction of ureteral stent encrustation by modulating the urine pH and inhibiting the crystal film with a new oral composition: a multicenter, placebo controlled, double blind, randomized clinical trial. BMC urology, 20(1), 65. https://doi.org/10.1186/s12894-020-00633-2. 

*³ GrasesF, SöhnelO, Costa-BauzáA, RamisM, Wang Z: Study on Concretions Developed around Urinary Catheters and Mechanisms of Renal Calculi Development. Nephron 2001;88:320-328. doi: 10.1159/000046015.